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1: Eur J cancer Prev 2001 Apr;10(2):153-6 Organochlorine pesticides in carcinoma of the gallbladder: a case-control study. Shukla VK Rastogi on, Adukia TK, Raizada RB, Reddy, S. Singh Department of surgery, Institute of medical sciences, Banaras Hindu University,. Varanasi, India. This email address is being protected from spambots. You need JavaScript enabled to view it. Carcinoma of the gallbladder is the third most common of the malignancy gastrointestinal tract in the Eastern Uttar Pradesh and Western Bihar regions of India. The main source of drinking water in this region is the river Ganges, which is heavily polluted with agricultural pesticides. Organochlorine pesticides were estimated gas in bile by liquid chromatography in 60 patients (30 carcinoma of the gallbladder and 30 cholelithiasis) to observe its Association with aetiopathogenesis of carcinoma of the gallbladder. The mean Biliary concentration of benzene hexachloride (BHC) which found to be significantly higher in carcinoma of the gallbladder (0.0471 ppm) than in cholelithiasis (0.0352 ppm) (P 0.04 t). The mean biliary concentration of dichlorodiphenyltrichloroethane (DDT) what so significantly higher in carcinoma of the gallbladder (0.418 ppm) than in cholelithiasis (0.0103 ppm) (P< 0.03).="" biliary="" aldrin="" and="" endosulfan="" concentrations="" were="" higher="" in="" carcinoma="" of="" the="" gallbladder="" (0.0008="" and="" 0.00132="" ppm)="" than="" in="" cholelithiasis="" (0.0005="" and="" 0.0126="" ppm)="" but="" the="" difference="" was="" statistically="" not="" significant="" (p="">< 0.06="" and="" p="">< 0.9).="" the="" levels="" of="" pesticides="" in="" blood="" did="" not="" show="" significant="" differences="" in="" either="" carcinoma="" of="" the="" gallbladder="" or="" cholelithiasis.="" significantly="" high="" biliary="" bhc="" and="" ddt="" concentrations="" suggest="" that="" these="" pesticides="" might="" be="" associated="" with="" gallbladder="" carcinogenesi.="" pmid:="" 11330456="" [pubmed="" -="" in="" process]="" 1:="" hum="" reprod="" 2001="" may;16(5):1020-1026="" sexual="" precocity="" after="" immigration="" from="" developing="" countries="" to="" belgium:="" evidence="" of="" previous="" exposure="" to="" organochlorine="" pesticides.="" krstevska-konstantinova="" m,="" charlier="" c,="" craen="" m,="" du="" caju="" m,="" heinrichs="" c,="" de="" beaufort="" c,="" plomteux="" g,="" bourguignon="" jp.="" division="" of="" ambulatory="" pediatrics="" and="" adolescent="" medicine,="" department="" of="" pediatrics="" and="" laboratory="" of="" toxicology,="" university="" of="" liege,="" c.h.u.="" sart="" tilman,="" liege,="" belgium="" and="" departments="" of="" pediatrics,="" universities="" of="" ghent,="" antwerp,="" brussels="" and="" centre="" hospitalier="" de="" luxembourg,="" in="" collaboration="" with="" the="" belgian="" study="" group="" for="" pediatric="" endocrinology.="" in="" a="" retrospective="" auxological="" study="" of="" 145="" patients="" seen="" in="" belgium="" during="" a="" 9-year="" period="" for="" treatment="" of="" precocious="" puberty,="" 28%="" appeared="" to="" be="" foreign="" children="" (39="" girls,="" one="" boy)="" who="" immigrated="" 4="" to="" 5="" years="" earlier="" from="" 22="" developing="" countries,="" without="" any="" link="" to="" a="" particular="" ethnic="" or="" country="" background.="" the="" patients="" were="" either="" adopted="" (n="28)" or="" non-adopted="" (n="12)," the="" latter="" having="" normal="" weight="" and="" height="" at="" immigration="" and="" starting="" early="" puberty="" without="" evidence="" of="" earlier="" deprivation.="" this="" led="" to="" the="" hypothesis="" that="" the="" mechanism="" of="" precocious="" puberty="" might="" involve="" previous="" exposure="" to="" oestrogenic="" endocrine="" disrupters.="" a="" toxicological="" plasma="" screening="" for="" eight="" pesticides="" detected="" p,p'-dde,="" which="" is="" derived="" from="" the="" organochlorine="" pesticide="" ddt.="" median="" p,p'-dde="" concentrations="" were="" respectively="" 1.20="" and="" 1.04="" ng/ml="" in="" foreign="" adopted="" (n="15)" and="" non-adopted="" (n="11)" girls="" with="" precocious="" puberty,="" while="" 13="" out="" of="" 15="" belgian="" native="" girls="" with="" idiopathic="" or="" organic="" precocious="" puberty="" showed="" undetectable="" concentrations=""><0.1 ng/ml). A possible relationship between transient exposure to endocrine disrupters and sexual precocity is suggested, and deserves further studies in immigrant children with non-advanced puberty. PMID: 11331654 [PubMed - as supplied by publisher] ng/ml).="" a="" possible="" relationship="" between="" transient="" exposure="" to="" endocrine="" disrupters="" and="" sexual="" precocity="" is="" suggested,="" and="" deserves="" further="" studies="" in="" immigrant="" children="" with="" non-advanced="" puberty.="" pmid:="" 11331654="" [pubmed="" -="" as="" supplied="" by="">