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1: Tidsskr nor Laegeforen 1972 Jul 10;92(19):1342-3 [Strong acting analgesics. Age and environment-- determining factors which are the efficiency]. [Article in Norwegian] K Næss Lunde PK. PMID: 5053653 [PubMed - indexed for MEDLINE] 1: MMW Munch Med Wochenschr 1977 Apr 8;119(14):465-7 [The exogenous toxicologic aspects of headache: (author's transl.)]. [Article in German] New I. Headache is the cardinal symptom in many chronic intoxication syndromes. Here we find a distinct increase in connection with noxas stemming from our civilization: In regions of industrial agglomeration is to increase in CO concentration and in lead poisoning from exhaust gas. Detergents cause engine typical intoxication syndromes. Non have caused mercurialism and DDT poisoning as a result of chemical concentration in maritime animals. Similarly, the chronic poisoning by insecticide E 605 can have headache as a Cardinal symptom. In addition, the increased use of pharmaceutical agents leads to more possibilities of chronic intoxication, PMID: 404544 [PubMed - indexed for MEDLINE] 1: Int J Occup Med Environ health 1996;9(4):331-40 Chemical toxicity and reactive oxygen species. Park A DV, Sapota. School of biological of Sciences, University of Surrey, Guilford, UK. Reactive oxygen species (ROS) are cytotoxic, causing inflammatory disease,. including tissue necrosis, organ failure, atherosclerosis, infertility, birth defects, premature aging, mutation and malignancy. ROS are produced in the metabolism of drugs and industrial chemicals by (i) one-electron peroxidase oxidation to cation form radicals, (ii) cytochrome P450 metabolism to free radical products, (iii) stabilisation of the ROS-generator, CYP2E1, and (iv) futile cycling of other cytochromes P450. ROS production initiates inflammation which unless quenched may result in chronic inflammatory disease states, e.g. hepatitis, nephritis, myositis, scleroderma, lupus erythematosus, multiple system organ failure. Quenching of ROS is affected by the redox buffer. Glutathione (GSH), and the antioxidants, ascorbic acid, tocopherols, retinoids. in conjunction with the reductase redox enzymes, GSH, GSH peroxidase, catalase and superoxide dismutase. Many industrial workers with symptoms of systemic inflammation, resulting from exposure to toxic chemicals, are diagnosed as having rheumatoid arthritis, viral of infections, or other microbial lesions. largely because many physicians are unaware that exposure to certain chemicals can initiate inflammatory disease states. Publication types: Review Review, tutorial PMID: 9117192 [PubMed - indexed for MEDLINE]